Skip to main navigation menu Skip to main content Skip to site footer
Academia Open

Medicine

Vol 9 No 1 (2024): June

Analyzing if calcium channel blockers can save pregnant patients with persistent hypertension from developing preeclampsia
Menganalisis apakah penghambat saluran kalsium dapat menyelamatkan pasien hamil dengan hipertensi persisten dari pengembangan preeklampsia



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.9.2024.8933
Published
May 13, 2024

Abstract

Pregnant women with chronic hypertension face elevated risks during pregnancy, necessitating effective management strategies. This study evaluates the potential benefits of combining low-dose aspirin therapy with calcium channel blockers, particularly nifedipine, in this population. Thirty-seven participants were enrolled between July 2015 and September 2017, receiving combination therapy as part of their treatment regimen. Results indicate effective blood pressure control without significant adverse events, with 36.8% experiencing preeclampsia but no severe cases reported. Neonatal outcomes were generally favorable, although 15% of babies were classified as small-for-gestational-age, all achieving Apgar scores between nine and ten. These findings suggest promising outcomes with combination therapy, emphasizing the need for further research to optimize management approaches for pregnant individuals with chronic hypertension.

Highlight:

  1. Controlled blood pressure: Combination therapy effectively manages blood pressure in chronic hypertension.
  2. Lowered severe complications: Potential reduction in eclampsia and placental abruption risks.
  3. Positive neonatal outcomes: Favorable Apgar scores and reduced small-for-gestational-age incidence.

Keywoard: Chronic Hypertension, Pregnancy, Combination Therapy, Low-Dose Aspirin, Calcium Channel Blockers

References

  1. A.V. Mattioli, S. Pennell, F. Demaria, A. Farinetti, "Atrial remodeling in pregnant hypertensive women: comparison between chronic and gestational hypertension," Open Cardiovasc. Med. J., vol. 6, p. 9, 2012.
  2. A.E. Czeizel, F. Banhidy, "Chronic hypertension in pregnancy," Curr. Opin. Obstet. Gynecol., vol. 23, no. 76, 2011.
  3. P.V. Garcia, C. Montufar-Rueda, A. Smith, "Pregnancy and severe chronic hypertension: maternal outcome," Hypertens. Pregnancy, vol. 23, p. 285, 2004.
  4. C. Lydakis, D.G. Beavers, M. Beavers, G.Y. Lip, "Obstetric and neonatal outcome following chronic hypertension in pregnancy among different ethnic groups," QJM, vol. 91, p. 837, 1998.
  5. L.A. Magee, C. Cham, E.J. Waterman, A. Ohlsson, P. von Dadelszen, "Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis," BMJ, vol. 327, p. 955, 2003.
  6. E.W. Seely, J. Ecker, "Clinical practice. Chronic hypertension in pregnancy," N. Engl. J. Med., vol. 365, p. 439, 2011.
  7. American College of Obstetricians and Gynecologists, "ACOG Practice Bulletin No. 125: Chronic hypertension in pregnancy," Obstet. Gynecol., vol. 119, p. 396, 2012.
  8. U. Perni, C. Sison, V. Sharma, G. Helseth, A. Hawfield, M. Suthanthiran, P. August, "Angiogenic factors in superimposed preeclampsia: a longitudinal study of women with chronic hypertension during pregnancy," Hypertension, vol. 59, p. 740, 2012.
  9. European Society of Gynecology (ESG), Association for European Paediatric Cardiology (AEPC), German Society for Gender Medicine (DGesGM), V. Regitz-Zagrosek, C. Blomstrom Lundqvist, C. Borghi, et al., "ESC Guidelines on the management of cardiovascular diseases during pregnancy: the task force on the management of cardiovascular diseases during pregnancy of the European Society of Cardiology (ESC)," Eur. Heart J., vol. 32, p. 3147, 2011.
  10. G. Mancia, R. Fagard, K. Narkiewicz, J. Redon, A. Zanchetti, M. Böhm, et al., "2013 ESH/ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)," Eur. Heart J., vol. 34, p. 2159, 2013. doi: 10.1093/eurheartj/eht151. Epub 2013 Jun 14.
  11. M. Jayashree, S. Singhi, "Changing trends and predictors of outcome in patients with acute poisoning admitted to the intensive care," J. Trop. Pediatr., vol. 57, p. 340, 2011.
  12. S.R. Helms, "Treatment of feline hypertension with transdermal amlodipine: a pilot study," J. Am. Anim. Hosp. Assoc., vol. 47, no. 3, p. 205, 2011.

Downloads

Download data is not yet available.