Skip to main navigation menu Skip to main content Skip to site footer
Academia Open

Medicine

Vol 9 No 1 (2024): June

Update About The Changes In Bacterial Resistance For Multiple Antibiotic In Patients With Urinary Tract Infection In Kerbala
Pembaruan Tentang Perubahan Resistensi Bakteri Untuk Beberapa Antibiotik Pada Pasien Infeksi Saluran Kemih Di Kerbala



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.9.2024.8928
Published
May 13, 2024

Abstract

Urinary tract infections (UTIs) caused by Escherichia coli (E. coli) are common and recurrent, particularly among females. Treatment often involves various antimicrobial agents, but rising resistance poses challenges. We conducted a study in Al-Hussein Medical City, Kerbala, enrolling 520 UTI patients from April 2022 to February 2023. Urine samples were tested for antimicrobial susceptibility. Results showed high resistance to most agents, except meropenem and levofloxacin. Our findings emphasize the urgent need for strategies to combat antimicrobial resistance in UTIs.

Highlights:

  1. High resistance in UTI treatment observed.
  2. Urgent need for antimicrobial resistance strategies.
  3. Study reveals E. coli resistance patterns in Kerbala's medical setting.

Keywords: Urinary tract infections, Escherichia coli, Antimicrobial resistance, Al-Hussein Medical City, Kerbala

References

  1. A. ‘t Hoen et al., "Update of the EAU/ESPU guidelines on urinary tract infections in children," J. Pediatr. Urol., vol. 17, no. 2, pp. 200-207, 2021.
  2. J. H. Albaramki et al., "Urinary tract infection caused by extended-spectrum β-lactamase-producing bacteria: Risk factors and antibiotic resistance," Pediatrics Int., vol. 61, no. 11, pp. 1127-1132, 2019.
  3. L. Atkins et al., "Reducing catheter-associated urinary tract infections: A systematic review of barriers and facilitators and strategic behavioural analysis of interventions," Implementation Sci., vol. 15, pp. 1-22, 2020.
  4. M. A. Belete and M. Saravanan, "A systematic review on drug resistant urinary tract infection among pregnant women in developing countries in Africa and Asia; 2005–2016," Infect. Drug Resist., vol. 13, pp. 1465-1477, 2020.
  5. G. K. Bunduki et al., "Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: A systematic review and meta-analysis," BMC Infect. Dis., vol. 21, pp. 1-13, 2021.
  6. Z. Dong et al., "Biological functions and molecular mechanisms of antibiotic tigecycline in the treatment of cancers," Int. J. Mol. Sci., vol. 20, no. 14, pp. 3577, 2019.
  7. A. A. Elshamy and K. M. Aboshanab, "A review on bacterial resistance to carbapenems: Epidemiology, detection and treatment options," Future Sci. OA, vol. 6, no. 3, pp. FSO438, 2020.
  8. A. Flores-Mireles et al., "Pathophysiology, treatment, and prevention of catheter-associated urinary tract infection," Top. Spinal Cord Injury Rehabil., vol. 25, no. 3, pp. 228-240, 2019.
  9. V. Folliero et al., "Prevalence and antimicrobial susceptibility patterns of bacterial pathogens in urinary tract infections in University Hospital of Campania 'Luigi Vanvitelli' between 2017 and 2018," Antibiotics, vol. 9, no. 5, pp. 215, 2020.
  10. M. Gajdács et al., "Characterization of resistance in gram-negative urinary isolates using existing and novel indicators of clinical relevance: A 10-year data analysis," Life, vol. 10, no. 2, pp. 16, 2020.
  11. R. Ganesh et al., "Epidemiology of urinary tract infection and antimicrobial resistance in a pediatric hospital in Nepal," BMC Infect. Dis., vol. 19, no. 1, pp. 1-5, 2019.
  12. G. Gebremariam et al., "Bacteriological profile, risk factors and antimicrobial susceptibility patterns of symptomatic urinary tract infection among students of Mekelle University, northern Ethiopia," BMC Infect. Dis., vol. 19, pp. 1-11, 2019.
  13. P. Katongole et al., "Biofilm formation, antimicrobial susceptibility and virulence genes of Uropathogenic Escherichia coli isolated from clinical isolates in Uganda," BMC Infect. Dis., vol. 20, no. 1, pp. 1-6, 2020.
  14. S. Larramendy et al., "Risk factors of extended-spectrum beta-lactamases-producing Escherichia coli community acquired urinary tract infections: A systematic review," Infect. Drug Resist., vol. 12, pp. 3945-3955, 2020.
  15. R. Laxminarayan et al., "The Lancet Infectious Diseases Commission on antimicrobial resistance: 6 years later," Lancet Infect. Dis., vol. 20, no. 4, pp. e51-e60, 2020.
  16. L. Leitner et al., "Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: A randomised, placebo-controlled, double-blind clinical trial," Lancet Infect. Dis., vol. 21, no. 3, pp. 427-436, 2021.
  17. A. L. Lewis and N. M. Gilbert, "Roles of the vagina and the vaginal microbiota in urinary tract infection: Evidence from clinical correlations and experimental models," GMS Infect. Dis., vol. 8, pp. 1-8, 2020.
  18. E. A. Oliveira and R. H. Mak, "Urinary tract infection in pediatrics: An overview," Jorn. Pediatr., vol. 96, pp. 65-79, 2020.
  19. P. Pachori et al., "Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; a critical review," Genes Dis., vol. 6, no. 2, pp. 109-119, 2019.
  20. S. Samarasinghe et al., "The anti-virulence effect of cranberry active compound proanthocyanins (PACs) on expression of genes in the third-generation cephalosporin-resistant Escherichia coli CTX-M-15 associated with urinary tract infection," Antimicrob. Resist. Infect. Control, vol. 8, no. 1, pp. 1-9, 2019.
  21. N. Shaikh et al., "Reassessment of the role of race in calculating the risk for urinary tract infection: A systematic review and meta-analysis," JAMA Pediatr., vol. 176, no. 6, pp. 569-575, 2022.
  22. C. Uruén et al., "Biofilms as promoters of bacterial antibiotic resistance and tolerance," Antibiotics, vol. 10, no. 1, pp. 3, 2021.
  23. M. Yazdi et al., "Isolation, characterization and genomic analysis of a novel bacteriophage VB_EcoS-Golestan infecting multidrug-resistant Escherichia coli isolated from urinary tract infection," Sci. Rep., vol. 10, no. 1, pp. 7690, 2020.
  24. I. Yelin et al., "Personal clinical history predicts antibiotic resistance of urinary tract infections," Nat. Med., vol. 25, no. 7, pp. 1143-1152, 2019.
  25. F. Yuan et al., "Pathogenesis of Proteus mirabilis in catheter-associated urinary tract infections," Urol. Int., vol. 105, no. 5-6, pp. 354- , 2021.

Downloads

Download data is not yet available.