Academia Open
Vol 10 No 1 (2025): June (In Progress)
Medicine

Inhibition of Propolis on the Growth of Aggregatibacter Actinomycetemcomitans
Daya Hambat Propolis terhadap Pertumbuhan Aggregatibacter Actinomycetemcomitans


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  • Novita Pratiwi*,
  • Anis Khoirin Hayati,
  • Nurul Maulidah
Novita Pratiwi
Universitas Muhammadiyah Sidoarjo, Indonesia *
Anis Khoirin Hayati
Universitas Muhammadoyah Sidoarjo, Indonesia
Nurul Maulidah
Universitas Muhammadiyah Sidoarjo, Indonesia

(*) Corresponding Author
Picture in here are illustration from public domain image or provided by the author, as part of their works
DOI: https://doi.org/10.21070/acopen.10.2025.10589
Published February 10, 2025
Keywords
  • Periodontitist,
  • Propolis,
  • Aggregatibacter Actinomycetemcomitans,
  • Antimicroba
How to Cite
Pratiwi, N., Hayati, A. K., & Maulidah, N. (2025). Inhibition of Propolis on the Growth of Aggregatibacter Actinomycetemcomitans. Academia Open, 10(1), 10.21070/acopen.10.2025.10589. https://doi.org/10.21070/acopen.10.2025.10589

Copyright (c) 2025 Novita Pratiwi, Anis Khoirin Hayati, Nurul Maulidah

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

General Background: Periodontitis, a chronic inflammatory disease, leads to tooth loss, with Aggregatibacter actinomycetemcomitans playing a key role in its pathogenesis. Specific Background: The rise of antibiotic resistance necessitates alternative treatments. Propolis, a bee-derived resin, has shown antimicrobial properties. Knowledge Gap: Limited research exists on the inhibitory effects of propolis against A. actinomycetemcomitans at varying concentrations. Aims: This study evaluates the antibacterial activity of propolis extract on A. actinomycetemcomitans in vitro. Results: Propolis exhibited significant antibacterial effects, with a minimum inhibitory concentration of 12.5% (125 mg/mL), attributed to flavonoids and apigenin. Statistical analysis confirmed significant differences across concentrations (p < 0.05). Novelty: This study highlights the concentration-dependent antibacterial efficacy of propolis against A. actinomycetemcomitans, suggesting its potential as a natural therapeutic. Implications: Propolis may serve as a complementary antimicrobial in periodontal therapy, reducing antibiotic reliance and resistance.

Highlights:

  • Effective Antibacterial Agent – Propolis inhibits A. actinomycetemcomitans growth at a minimum concentration of 12.5% (125 mg/mL).
  • Bioactive Components – Flavonoids and apigenin in propolis disrupt bacterial membranes and biofilm formation.
  • Clinical Potential – Propolis may serve as a natural alternative to antibiotics in periodontal therapy.

Keywords: Periodontitist, Propolis, Aggregatibacter Actinomycetemcomitans, Antimicroba

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References

  1. M. G. Newman and H. H. Takei, Clinical Periodontology, 13th ed. Philadelphia, PA, USA: W.B. Saunders, 2018, pp. 70–76, 200–207, 798–803.
  2. E. G. S. Maulana and F. Heriyani, "Factors Affecting Tooth Loss at Ages 35–44 in Juai District, Balangan Regency," Dentino, vol. 1, no. 1, pp. 98–103, 2016.
  3. J. L. Ebersole, S. C. Holt, R. Hansard, and M. J. Novak, "Microbiologic and Immunologic Characteristics of Periodontal Disease in Hispanic Americans with Type 2 Diabetes," J. Periodontol., vol. 79, pp. 637–646, 2008.
  4. N. Nørskov-Lauritsen, R. Claesson, A. B. Jensen, C. H. Åberg, and D. Haubek, "Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Undergoing Multiple Classification and Nomenclature Changes," Pathogens, vol. 8, p. 243, 2019.
  5. A. Kulkarni, M. D. Beckler, S. S. Amini, and M. M. Kesselman, "Oral Microbiome in Pre-Rheumatoid Arthritis: The Role of Aggregatibacter Actinomycetemcomitans in Bacterial Composition," Cureus, 2022.
  6. S. G. Ganiswarna, Pharmacology and Therapy, 5th ed. Jakarta, Indonesia: UI Press, 2007.
  7. V. Bankova, M. Popova, and B. Trusheva, "Propolis Volatile Compounds: Chemical Diversity and Biological Activity? A Review," Propolis J., vol. 8, pp. 28–35, 2014.
  8. W. Wininingsih, "Bee Residences as Antibiotics and Anti-Cancer Agents," Lintas Beritas, 2007. [Online]. Available: http://www.lintasberitas.com
  9. L. D. Lestari, Noverita, and A. Permana, "Inhibitory Effect of Propolis on Staphylococcus Aureus and Escherichia Coli," J. Pro-Life, vol. 7, no. 3, pp. 237–250, 2020.
  10. G. Katzung, Basic and Clinical Pharmacology, 14th ed. Jakarta, Indonesia: Penerbit Buku Kedokteran EGC, 2023, pp. 51–53.
  11. C. Guyton and J. E. Hall, Textbook of Medical Physiology, 14th ed. Philadelphia, PA, USA: Saunders, 2021, pp. 110–112.
  12. W. M. A. Alaerjani et al., "Chemical Profiling, Antioxidant, and Antimicrobial Activity of Saudi Propolis Collected by Arabian Honey Bee (Apis Mellifera Jemenitica) Colonies," Antioxidants, vol. 11, no. 7, J. Appl. Oral Sci., vol. 15, no. 5, pp. 420–423, 2022.
  13. Siswandono and B. Soekardjo, Medicinal Chemistry 2, 2nd ed. Surabaya, Indonesia: Airlangga University Press, 2016.
  14. Z. Meilawaty et al., "Antibacterial Test of Cassava Leaf (Manihot Esculenta Crantz) Extract Against Fusobacterium Nucleatum and Aggregatibacter Actinomycetemcomitans," 2022.
  15. D. A. Suhendro, "Effectiveness of Lactobacillus Casei and Lactobacillus Reuteri in Inhibiting the Growth of Porphyromonas Gingivalis and Aggregatibacter Actinomycetemcomitans: An In Vitro Study," Undergraduate Thesis, 2021.