Skip to main navigation menu Skip to main content Skip to site footer
Academia Open

Microbiology

Vol 9 No 1 (2024): June

Anti-Bacterial Activity of Procaine_4_ Hydroxycoumarin - Aqueous Copper Chloride
Aktivitas Anti-Bakteri dari Procaine_4_ Hydroxycoumarin - Tembaga Klorida Berair



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.9.2024.10356
Published
June 18, 2024

Abstract

Background: The presence of a -N=N- double bond with two substituents, often aromatic rings, is what distinguishes azo compounds. Because of their exceptional qualities, azo dyes and their derivatives have become promising antibacterial substances. Materials and methods: The procaine_4_ hydroxycoumarin - aqueous copper chloride {C9H6O3-C13H20N2O2 -CUCI2.H2O} was prepared by many reactions, and tested as an antibacterial compound against (Pseudomonas aeruginosa, Staphylococcus sp., Proteus mirabilis, Shegilla sp, and Escherichia coli) according to the agar diffusion method. Results: The compound showed antibacterial activity against all bacterial isolates, two of which were resistant to antibiotics such as amikacin and amoxicillin. Conclusion:  The ligand and its metal complex are known as biologically antibacterial

Highlights:

 

  1. Azo compounds with aromatic rings exhibit promising antibacterial properties.
  2. Procaine_4_hydroxycoumarin-copper chloride tested via agar diffusion method.
  3. Effective against bacteria, including antibiotic-resistant strains like E. coli.

 

Keywords: Anti-bacterial, Azo dye, procaine_4_ hydroxycoumarin- aqueous copper chloride

References

  1. . N. F. Abbas and A. K. Abbas, "Novel Complexes of Thiobarbituric Acid-Azo Dye: Structural, Spectroscopic, Biological Activity and Dying," Biochem. Cell. Arch., vol. 20, no. 1, pp. 2419–2433, 2020.
  2. . H. H. Abdul-Ra’aoof, M. A. Akber, F. A. Jassim, A. M. Tiryag, S. S. Issa, M. A. Atiyah, et al., "The Psychological Impact of Violence on Emergency Department and Intensive Care Unit Nurses: A Cross-Sectional Study," Res. J. Trauma and Disabil. Stud., vol. 3, no. 4, pp. 228–233, 2024.
  3. . H. H. Abdul-Ra’aoof, S. B. Dawood, F. A. Jassim, S. K. Jassim, S. S. Issa, M. A. Akber, and M. A. Atiyah, "Moderate Proficiency in Suture Techniques Among Nurses: A Cross-Sectional Study," J. Nurs. Educ. Pract., vol. 14, no. 2, pp. 50–58, 2024.
  4. . H. H. Abdul-Ra’aoof, A. M. Tiryag, and M. A. Atiyah, "Knowledge, Attitudes, and Practice of Nursing Students About Insulin Therapy: A Cross-Sectional Study," Academia Open, vol. 9, no. 1, p. 10-21070, 2024.
  5. . N. M. Aljamali and H. S. Hassen, "Review on Azo-Compounds and Their Applications," J. Catal. Catalysis, vol. 8, no. 2, pp. 8–16, 2021.
  6. . H. M. Al-Saidi, G. A. Gouda, M. Abdel-Hakim, N. I. A. Alsenani, M. H. Mahross, O. A. Farghaly, and S. Hosny, "Synthesis, Structural Characterization, and Molecular Modeling of Bidentate Azo Dye Metal Complexes: DNA Interaction to Antimicrobial and Anticancer Activities," Appl. Organomet. Chem., vol. 32, no. 3, p. e4136, 2018.
  7. . J. Chen, D. Wei, L. Liu, J. Nai, Y. Liu, Y. Xiong, et al., "Green Synthesis of Konjac Glucomannan Templated Palladium Nanoparticles for Catalytic Reduction of Azo Compounds and Hexavalent Chromium," Mater. Chem. Phys., vol. 267, p. 124651, 2021.
  8. . H. A. El-Ghamry, S. K. Fathalla, and M. Gaber, "Synthesis, Structural Characterization, and Molecular Modeling of Bidentate Azo Dye Metal Complexes: DNA Interaction to Antimicrobial and Anticancer Activities," Appl. Organomet. Chem., vol. 32, no. 3, p. e4136, 2018.
  9. . R. Ganjoo, C. Verma, A. Kumar, and M. A. Quraishi, "Colloidal and Interface Aqueous Chemistry of Dyes: Past, Present and Future Scenarios in Corrosion Mitigation," Adv. Colloid Interface Sci., vol. 311, p. 102832, 2023.
  10. . F. S. Hosny, "Synthesis and Characterization of Ni(II), Cu(II), Zn(II) and Azo Dye Based on 1,10-o-Phenanthroline Binary Complexes: Corrosion Inhibition Properties and Computational Studies," Int. J. Electrochem. Sci., vol. 17, no. 3, Article 220333, 2022.
  11. . N. A. Razali and Z. Jamain, "Synthesis, Chemical Identification, and Biological Application of Azo-Based Molecules Containing Different Terminal Groups: A Review," J. Mol. Struct., vol. 1284, p. 135329, 2023.
  12. . S. S. Sandhu, S. Kumar, and R. P. Aharwal, "Isolation and Identification of Endophytic Fungi from Ricinus communis-Linn. and Their Antibacterial Activity," Biochem. Cell. Arch., pp. 611–618, 2014.
  13. . A. S. Waheeb and K. J. Al-Adilee, "Synthesis, Characterization, and Antimicrobial Activity Studies of New Heterocyclic Azo Dye Derived from 2-Amino-4,5-Dimethyl Thiazole with Some Metal Ions," Mater. Today Proc., vol. 42, pp. 2150–2163, 2021.
  14. . L.-X. Zhuang, L. Yi, C. Li-Hua, H. Yan-Jun, Y. Jun, and H. Pei-Zhi, "Thermal Behavior and Antimicrobial Properties of Azo Compounds," Thermochim. Acta, vol. 440, p. 51, 2006.
  15. . S. Zafar, D. A. Bukhari, and A. Rehman, "Azo Dyes Degradation by Microorganisms – An Efficient and Sustainable Approach," Saudi J. Biol. Sci., vol. 29, no. 12, p. 103437, 2022.

Downloads

Download data is not yet available.