Microbiology
Vol 9 No 1 (2024): June
Multidrug Resistant Bacteria Isolated From Some Basrah Hospitals
Bakteri Resistan Multiobat Diisolasi Dari Beberapa Rumah Sakit Di Basrah
MSc., Department of biology-College of sciences-University of Basrah, Iraq
*
PhD., department of basic science College of Nursing, University of Basrah, Basrah, Iraq, Iraq
(*) Corresponding Author
Abstract
General Background: Antibiotic resistance is a significant and growing public health concern, especially in hospital settings, where intensive care units (ICUs) often harbor multidrug-resistant organisms. Specific Background: Antimicrobial resistance in ICUs is a significant issue, necessitating a thorough assessment of bacterial susceptibility patterns to develop effective treatment protocols. Knowledge Gap: Despite the increasing concern, comprehensive studies focusing on bacterial resistance patterns in ICUs, particularly in diverse hospital settings, remain limited. Aims: The study aimed to assess the resistance patterns of bacterial isolates from blood, urine, and ICU surfaces to various antibiotics and identify the most resistant species. Results: Thirty blood, twenty urine, and fifty-six environmental samples were collected and cultured. Staphylococcus spp. exhibited 75% resistance to erythromycin, while Klebsiella spp., Pantoea spp., and E. coli showed 100% resistance to multiple antibiotics, including Ticarcillin, Piperacillin, and Cefixime. Confirmatory bacterial identification was performed using the Vitek 2 compact system, and resistance was measured across 25 antibiotics from various classes. Novelty: The study highlights the alarming 100% antibiotic resistance in various ICU-associated bacterial species, emphasizing the urgent need for revised antibiotic stewardship programs. Implications: The study underscores the importance of monitoring AMR patterns in hospitals and adjusting antibiotic therapies to combat rising resistance, particularly in ICUs, highlighting the need for robust surveillance.
Highlights:
- 100% resistance: Klebsiella, Pantoea, E. coli resist multiple antibiotics in ICU.
- ICU risk: Multidrug-resistant bacteria prevalent in intensive care units.
- Urgent need: Update antibiotic protocols, enhance AMR surveillance in hospitals.
Keywords: Antibiotic resistance, ICU, bacterial susceptibility, multidrug-resistant organisms, hospital infections
References
- . J. L. Vincent, D. J. Bihari, P. M. Suter, H. A. Bruining, J. White, M. H. Nicolas-Chanoin, et al., "The prevalence of nosocomial infection in intensive care units in Europe: Results of the European Prevalence of Infection in Intensive Care (EPIC) Study," JAMA, vol. 274, pp. 639–644, 1995.
- . J. Vaqué, J. Rossello, A. Trilla, V. Monge, J. Garcia-Caballero, J. L. Arribas, et al., "Nosocomial infections in Spain: Results of five nationwide serial prevalence surveys (EPINE project, 1990 to 1994)," Infection Control and Hospital Epidemiology, vol. 17, pp. 293–297, 1996.
- . M. E. Jones, D. C. Draghi, C. Thornsberry, J. A. Karlowsky, D. F. Sahm, and R. P. Wenzel, "Emerging resistance among bacterial pathogens in the intensive care unit: A European and North American surveillance study (2000-2002)," Annals of Clinical Microbiology and Antimicrobials, vol. 3, p. 14, 2004, doi: 10.1186/1476-0711-3-14.
- . U. Hadi, D. O. Duerink, E. S. Lestari, N. J. Nagelkerke, M. Keuter, D. Huis in't Veld, et al., "Audit of antibiotic prescribing in two governmental teaching hospitals in Indonesia," Clinical Microbiology and Infection, vol. 14, pp. 698–707, 2008.
- . G. G. Zanel, M. DeCorby, N. Laing, B. Weshnoweski, R. Vashisht, F. Tailor, et al., "Antimicrobial-resistant pathogens in intensive care units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006," Antimicrobial Agents and Chemotherapy, vol. 52, no. 4, pp. 1430–1437, 2008.
- . S. K. Fridkin, "Increasing prevalence of antimicrobial resistance in intensive care units," Critical Care Medicine, vol. 29, pp. 64–68, 2001.
- . O. Denis, C. Nonhoff, and M. J. Dowzicky, "Antimicrobial susceptibility among gram-positive and gram-negative isolates collected in Europe between 2004 and 2010," Journal of Global Antimicrobial Resistance, vol. 2, no. 3, pp. 155–161, 2014, doi: 10.1016/j.jgar.2014.05.001.
- . Z. Zong, A. Wu, and B. Hu, "Infection control in the era of antimicrobial resistance in China: Progress, challenges, and opportunities," Clinical Infectious Diseases, vol. 71, suppl. 4, pp. S372–S378, 2020, doi: 10.1093/cid/ciaa1514.
- . N. Akhtar, "Hospital-acquired infections in a medical intensive care unit," Journal of the College of Physicians and Surgeons Pakistan, vol. 20, pp. 386–390, 2010.
- . A. Gikas, J. Pediaditis, J. A. Papadakis, J. Starakis, S. Levidiotou, P. Nikolaides, et al., "Prevalence study of hospital-acquired infections in 14 Greek hospitals: Planning from the local to the national surveillance level," Journal of Hospital Infection, vol. 50, pp. 269–275, 2002, doi: 10.1053/jhin.2002.1181.
- . I. Jroundi, I. Khoudri, A. Azzouzi, A. A. Zeggwagh, N. F. Benbrahim, F. Hassouni, et al., "Prevalence of hospital-acquired infection in a Moroccan university hospital," American Journal of Infection Control, vol. 35, pp. 412–416, 2007, doi: 10.1016/j.ajic.2006.06.010.
- . T. A. Madani, N. A. Al-Abdullah, A. A. Al-Sanousi, T. M. Ghabrah, S. Z. Afandi, and H. A. Bajunid, "Methicillin-resistant Staphylococcus aureus in two tertiary-care centers in Jeddah, Saudi Arabia," Infection Control and Hospital Epidemiology, vol. 22, pp. 211–216, 2001, doi: 10.1086/501891.
- . M. Radji, S. Fauziah, and N. Aribinuko, "Antibiotic sensitivity pattern of bacterial pathogens in the intensive care unit of Fatmawati Hospital, Indonesia," Asian Pacific Journal of Tropical Biomedicine, vol. 1, no. 1, pp. 39–42, Jan. 2011.
- . L. Tian, Z. Zhang, and Z. Sun, "Antimicrobial resistance trends in bloodstream infections at a large teaching hospital in China: A 20-year surveillance study (1998-2017)," Antimicrobial Resistance and Infection Control, vol. 8, p. 86, 2019, doi: 10.1186/s13756-019-0545-z.
- . S. M. Al Johani, J. Akhter, H. Balkhy, A. El-Saed, M. Younan, and Z. Memish, "Prevalence of antimicrobial resistance among gram-negative isolates in an adult intensive care unit at a tertiary care center in Saudi Arabia," Annals of Saudi Medicine, vol. 30, pp. 364–369, 2010.
- . L. D. Bobo and E. R. Dubberke, "Recognition and prevention of hospital-associated enteric infections in the intensive care unit," Critical Care Medicine, vol. 38, suppl. S324–334, 2010.
- . "Policy of clinical application of antimicrobial drug use," Ministry of Health of the People's Republic of China, 2011. [Online]. Available: http://www.moh.gov.cn/mohyzs/s3586/201203/54251.shtml. Accessed Apr. 15, 2016. (in Chinese).
- . A. A. Maher, "Knowledge of nursing college students on preventive measures for irritable bowel syndrome: Pre-experimental study," International Journal of Integrative and Modern Medicine, vol. 2, no. 3, pp. 16–24, 2024.
- . M. Atiyah, "Nurses' knowledge regarding management of hypovolemic shock: A cross-sectional study," Academia Open, vol. 9, no. 2, p. 10-21070, May 2024.
- . S. S. Hamid, W. D. Ali, and M. A. Atiyah, "Assessing nursing students' knowledge of sleeve gastrectomy effects," Academia Open, vol. 9, no. 2, p. 10-21070, Jun. 2024.
- . A. M. Tiryag, M. A. Atiyah, and A. S. Khudhair, "Nurses' knowledge and attitudes toward thyroidectomy: A cross-sectional study," Health Education and Health Promotion, vol. 10, no. 3, pp. 459–465, Jul. 2022.
- . H. H. Abdul-Ra'aoof, M. A. Akber, F. A. Jassim, A. M. Tiryag, S. S. Issa, M. A. Atiyah, et al., "The psychological impact of violence on emergency department and intensive care unit nurses: A cross-sectional study," Research Journal of Trauma and Disability Studies, vol. 3, no. 4, pp. 228–233, Apr. 2024.
- . M. A. Atiyah and M. F. Hasan, "Assessment of pharmacy staff knowledge towards prevention of osteoporosis in adolescent girls," Age, vol. 20, no. 6, pp. 30–39.
- . W. D. Ali, D. R. Hashoosh, H. S. Mishet, S. H. Sabri, and M. A. Atiyah, "Assessing nurses' knowledge on medication to reduce errors in Iraq," Academia Open, vol. 9, no. 2, p. 10-21070, Sep. 2024.
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