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Academia Open

Microbiology

Vol 9 No 2 (2024): December

E. coli Strains in Iraq Show High Antibiotic Resistance and Virulence Potential
Strain E. coli di Irak Menunjukkan Resistensi Antibiotik yang Tinggi dan Potensi Virulensi



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.9.2024.9868
Published
August 23, 2024

Abstract

General Background: Escherichia coli is a widely distributed species that includes strains ranging from highly pathogenic to harmless avirulent isolates, often found in the human gut. Specific Background: E. coli pathogenicity is determined by virulence factors like adhesins, invasins, toxins, and capsules, which are often transferred horizontally via phages and plasmids. Knowledge Gap: Despite advancements in understanding E. coli virulence, there is a need to further understand genetic factors contributing to urinary tract infections, especially in regions with high antibiotic resistance. Aims: The study investigated the prevalence of virulence genes and antibiotic resistance in E. coli strains from UTI patients at Al Hussien Teaching Hospital in Iraq. Results: The study reveals the presence of specific virulence genes in UPEC strains from a specific region, suggesting the potential involvement of the pap AH gene in UTI pathogenesis. Novelty: This study reports the prevalence of specific virulence genes in UPEC strains from a specific region, indicating the potential role of the pap AH gene in UTI pathogenesis. Implications: The study indicates that UPEC strains, characterized by high virulence factors like pap AH, are promising vaccine targets, necessitating further research for effective prevention strategies.

Highlights:

 

  1. E. coli strains show high antibiotic resistance in UTI patients.
  2. pap AH gene is crucial for UPEC virulence.
  3. Virulence factors like pap AH are potential vaccine targets.

 

Keywords: E. coli, UTI, virulence factors, antibiotic resistance, pap AH gene

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