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Academia Open

Clinical Research

Vol 9 No 2 (2024): December

The Study On Antioxidant And Anti-Inflammatory Effects Of Sodium Copper Chlorophyllin In Male Rats Receiving Indomethacin



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.9.2024.9223
Published
July 7, 2024

Abstract

Sodium copper chlorophyllin (SC-C) is widely used for its biological properties and color. This study evaluated SC-C's antioxidative and anti-inflammatory effects in male rats treated with indomethacin. Fifty rats were divided into five groups: control, indomethacin, rabeprazole, and two SC-C dosages (35 mg/kg and 70 mg/kg). Indomethacin reduced serum GPx levels, but rabeprazole and SC-C treatments restored them. MDA levels increased with indomethacin but normalized with other treatments. Indomethacin also lowered IL-10, IL-4, and TNF, which returned to normal in treated groups. Histopathology showed SC-C reversed liver damage from indomethacin. SC-C demonstrates strong antioxidant and anti-inflammatory activities, suggesting its potential as a therapeutic agent.

Highlight:

 

  1. SC-C significantly restores serum GPx levels reduced by indomethacin.
  2. SC-C normalizes MDA, IL-10, IL-4, and TNF levels, countering oxidative stress.
  3. Histopathology shows SC-C reverses liver damage induced by indomethacin.

 

Key wards: Sodium copper chlorophyllin, antioxidant, anti-inflammatory, indomethacin, oxidative stress

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