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Academia Open

Medicine

Vol 9 No 2 (2024): December

Nano Quercetin Accelerates Wound Healing in Laboratory Mice
Nano Quercetin Mempercepat Penyembuhan Luka pada Tikus Laboratorium



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.9.2024.8979
Published
May 16, 2024

Abstract

This study explores the use of Curecetin nanoparticles, synthesized and characterized through X-ray Diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FTIR), and measured using Scanning Electron Microscopy (SEM) with sizes ranging from 13.40 to 44.66 nm. We conducted in vivo experiments on laboratory animals, applying nanoparticle doses of 10 mg, 50 mg, and 100 mg to 30 mm wounds. Skin wounds pose significant medical challenges due to potential complications like rupture and delayed healing. Results indicated that Curecetin nanoparticles significantly accelerated wound healing, with wound size reduction observed as early as the second day and substantial healing by the eighth day, suggesting the potential of nanoparticles in therapeutic applications for skin wounds.

Highlights:

  • Precise Characterization: Curecetin nanoparticles were precisely synthesized and characterized using XRD, FTIR, and SEM.
  • Rapid Healing: The study showed that Curecetin nanoparticles significantly accelerated wound healing in laboratory animals.
  • Clinical Potential: Results indicate a promising future for nanoparticle applications in treating skin wounds clinically.

Keywords: Nanoparticles, Curecetin, Wound Healing, Nanotechnology, Organism

References

  1. H. Sorg, D. J. Tilkorn, S. Hager, J. Hauser, and U. Mirastschijski, "Skin Wound Healing: An Update on the Current Knowledge and Concepts," European Surgical Research, vol. 58, no. 1-2, pp. 81-94, 2017.
  2. V. Falanga, R. R. Isseroff, A. M. Soulika, M. Romanelli, D. Margolis, S. Kapp, and K. Harding, "Chronic Wounds," Nature Review Disease Primers, vol. 8, no. 1, p. 50, 2022.
  3. E. Eriksson, P. Y. Liu, G. S. Schultz, M. M. Martins‐Green, R. Tanaka, D. Weir, and G. C. Gurtner, "Chronic Wounds: Treatment Consensus," Wound Repair and Regeneration, vol. 30, no. 2, pp. 156-171, 2022.
  4. A. E. Al-Snafi, "Medicinal Plants Alkaloids, as Promising Therapeutics-A Review (Part 1)," IOSR J Pharm, vol. 11, no. 2, pp. 51-67, 2021.
  5. J. O. Adeyemi, A. O. Oriola, D. C. Onwudiwe, and A. O. Oyedeji, "Plant Extracts Mediated Metal-Based Nanoparticles: Synthesis and Biological Applications," Biomolecules, vol. 12, no. 5, p. 627, 2022.
  6. B. M. Abdul Latif and M. W. Mahdi Alzubaidy, "Effect of Zinc Oxide Nanoparticles on Activity of Skin Cancer Cell Line (A-375)," in AIP Conference Proceedings, vol. 2593, no. 1, 2023.
  7. B. M. A. Latif and M. W. M. Alzubaidy, "Effect of Zinc Oxide Nanoparticles on Activity of Cell Line (B16) Causes Skin Cancer," NVEO-Natural Volatiles & Essential Oils Journal, pp. 472-478, 2021.
  8. A. Y. Aljohar, G. Muteeb, Q. Zia, S. Siddiqui, M. Aatif, M. Farhan, and M. I. Ahamed, "Anticancer Effect of Zinc Oxide Nanoparticles Prepared by Varying Entry Time of Ion Carriers Against A431 Skin Cancer Cells in Vitro," Frontiers in Chemistry, vol. 10, p. 1069450, 2022.
  9. A. A. Neamtu, T. A. Maghiar, A. Alaya, N. K. Olah, V. Turcus, D. Pelea, and E. Mathe, "A Comprehensive View on the Quercetin Impact on Colorectal Cancer," Molecules, vol. 27, no. 6, p. 1873, 2022.
  10. C. Forni, M. Rossi, I. Borromeo, G. Feriotto, G. Platamone, C. Tabolacci, and S. Beninati, "Flavonoids: A Myth or a Reality for Cancer Therapy?," Molecules, vol. 26, no. 12, p. 3583, 2021.
  11. O. M. Vincent, J. M. Nguta, E. S. Mitema, F. M. Musila, D. M. Nyak, A. H. Mohammed, and M. A. Gervason, "Ethnopharmacology, Pharmacological Activities, and Chemistry of the Hypericum Genus," J. Phytopharmacol, vol. 10, p. 105-113, 2021.
  12. M., Pongrac, I. M. Capjak, K. Ilić, E. Vrček, M. Ćurlin, and I. Pavičić, "Particle Surface Functionalization Affects Mechanism of Endocytosis and Adverse Effects of Silver Nanoparticles in Mammalian Kidney Cells," Journal of Applied Toxicology, vol. 43, no. 3, pp. 416-430, 2023.
  13. R. Abbasi, G. Shineh, M. Mobaraki, S. Doughty, and L. Tayebi, "Structural Parameters of Nanoparticles Affecting Their Toxicity for Biomedical Applications: A Review," Journal of Nanoparticle Research, vol. 25, no. 3, p. 43, 2023.
  14. A. M. Shehabeldine, S. S. Salem, O. M. Ali, K. A. Abd-Elsalam, F. M. Elkady, and A. H. Hashem, "Multifunctional Silver Nanoparticles Based on Chitosan: Antibacterial, Antibiofilm, Antifungal, Antioxidant, and Wound-Healing Activities," Journal of Fungi, vol. 8, no. 6, p. 612, 2022.
  15. F. Jiang, C. Du, N. Zhao, W. Jiang, X. Yu, and S. K. Du, "Preparation and Characterization of Quinoa Starch Nanoparticles as Quercetin Carriers," Food Chemistry, vol. 369, p. 130895, 2022.
  16. R. F. Egerton, M. Hayashida, and M. Malac, "Transmission Electron Microscopy of Thick Polymer and Biological Specimens," Micron, vol. 169, p. 103449, 2023.
  17. M. W. M. Alzubaidy and M. N. Hussain, "Biosynthetic of Green Zinc Oxide Nanoparticles with Effect on Cancer Cell Line Hela," Revis Bionatura, vol. 8, no. 2, p. 22, 2023.
  18. S. R. Falsafi, H. Rostamabadi, and S. M. Jafari, "X-Ray Diffraction (XRD) of Nanoencapsulated Food Ingredients," in Characterization of Nanoencapsulated Food Ingredients, Academic Press, pp. 271-293, 2020.
  19. S. Errico, M. Moggio, N. Diano, M. Portaccio, and M. Lepore, "Different Experimental Approaches for Fourier-Transform Infrared Spectroscopy Applications in Biology and Biotechnology: A Selected Choice of Representative Results," Biotechnology and Applied Biochemistry, vol. 70, no. 3, pp. 937-961, 2023.
  20. Y. Anagun, S. Isik, M. Olgun, O. Sezer, Z. B. Basciftci, and N. G. A. Arpacioglu, "The Classification of Wheat Species Based on Deep Convolutional Neural Networks Using Scanning Electron Microscope (SEM) Imaging," European Food Research and Technology, vol. 249, no. 4, pp. 1023-1034, 2023.
  21. M. W. Mahdi Alzubadiy, A. M. Salih Almohaidi, A. Ahmed Sultan, and L. Qasim Abdulhameed, "Evaluation of E-selectin rs 5367 C/T Polymorphism in Iraqi Diabetic Foot Patients," Journal of Physics: Conference Series, vol. 1294, p. 062021, 2019.
  22. C. W. Huo, G. Chew, P. Hill, D. Huang, W. Ingman, L. Hodson, and K. Britt, "High Mammographic Density Is Associated with an Increase in Stromal Collagen and Immune Cells Within the Mammary Epithelium," Breast Cancer Research, vol. 17, p. 1-20, 2015.

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