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Academia Open

Science

Vol 9 No 2 (2024): December

Circulating Microrna-146a as A Biomarker Related To Inflammation in Thalasemia Patients



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.9.2024.8120
Published
October 11, 2023

Abstract

This study delves into the intricate realm of microRNAs (miRNAs), non-coding RNA molecules that wield significant influence in the pathogenesis of various disorders. With the advent of advanced technologies, accurate quantification of miRNA abundance across diverse tissues is now attainable. Notably, extracellular circulating microparticles have emerged as robust, stable indicators for blood-based disease diagnostics. This investigation explores the dynamic interplay between circulating microparticles and clinical phenotypes, offering valuable insights into disease intricacies. The research narrows its focus to recent developments in employing circulating microparticles as biomarkers for prevalent inflammatory disorders, including infections endemic to thalassemia patients in the city of Diwaniyah, Iraq. Current findings paint a promising future for the utilization of circulating microparticles in the management of inflammatory diseases. In conclusion, this comprehensive exploration of miRNA's regulatory role in globin gene expression has the potential to revolutionize the landscape of thalassemia, ameliorating clinical manifestations and symptoms of this debilitating hemoglobinopathy. The identification of miRNAs implicated in the disease's pathophysiology not only paves the way for novel diagnostic markers but also opens new horizons for therapeutic interventions.

Highlights :

  • MiRNA Significance: MicroRNAs play a pivotal role in the pathogenesis of various disorders, offering potential insights into disease mechanisms.

  • Circulating Microparticles: Extracellular circulating microparticles are stable blood-based indicators, holding promise for disease diagnostics and management, especially in the context of inflammatory disorders.

  • Thalassemia Insights: This study highlights the potential impact of miRNAs on globin gene expression, offering new avenues for the diagnosis and treatment of thalassemia, a debilitating hemoglobinopathy.

Keywords : MicroRNAs (miRNAs), Circulating Microparticles, Thalassemia, Inflammatory Disorders, Disease Diagnostics

References

  1. E. Franco, K. A. Karkoska, and P. T. McGann, "Inherited disorders of hemoglobin: A review of old and new diagnostic methods," Blood Cells, Molecules, and Diseases, 2023.
  2. A. Lal and E. Vichinsky, "The clinical phenotypes of alpha thalassemia," Hematology/Oncology Clinics, vol. 37, no. 2, pp. 327-339, 2023.
  3. E. J. Benz, "Introduction to the Thalassemia Syndromes: Molecular Medicine’s Index Case," Hematology/Oncology Clinics, vol. 37, no. 2, pp. 245-259, 2023.
  4. A. Mardhiyah, S. L. Panduragan, H. S. Mediani, and I. Yosep, "Nursing Interventions to Improve Quality of Life Among Children and Adolescents with Thalassemia: A Scoping Review," Journal of Multidisciplinary Healthcare, pp. 1749-1762, 2023.
  5. R. Lone, P. Yousuf, S. Razzak, and S. Parvaiz, "MicroRNA-mediated Regulation of Herbicide Resistance," Plant MicroRNAs and Stress Response, pp. 220-241, 2023.
  6. M. Machowska, P. Galka-Marciniak, and P. Kozlowski, "Consequences of genetic variants in miRNA genes," Computational and Structural Biotechnology Journal, 2022.
  7. T. Di Mambro, G. Pellielo, E. D. Agyapong, M. Carinci, D. Chianese, C. Giorgi, et al., "The tricky connection between extracellular vesicles and mitochondria in inflammatory-related diseases," International Journal of Molecular Sciences, vol. 24, no. 9, p. 8181, 2023.
  8. M. A. Sultana, R. A. Hia, O. Akinsiku, and V. Hegde, "Peripheral Mitochondrial Dysfunction: A Potential Contributor to the Development of Metabolic Disorders and Alzheimer’s Disease," Biology, vol. 12, no. 7, p. 1019, 2023.
  9. T. Levinson, E. Feigin, S. Berliner, S. Shenhar-Tsarfaty, I. Shapira, O. Rogowski, et al., "Normoferremia in Patients with Acute Bacterial Infections—A Hitherto Unexplored Field of the Dichotomy between CRP and Ferritin Expression in Patients with Hyper Inflammation and Failure to Increase Ferritin," International Journal of Molecular Sciences, vol. 24, no. 14, p. 11350, 2023.
  10. P. Caprari, E. Profumo, S. Massimi, B. Buttari, R. Riganò, V. Regine, et al., "Hemorheological profiles and chronic inflammation markers in transfusion-dependent and non-transfusion-dependent thalassemia," Frontiers in Molecular Biosciences, vol. 9, p. 1108896, 2023.
  11. A. Gluba-Brzózka, B. Franczyk, M. Rysz-Górzyńska, R. Rokicki, M. Koziarska-Rościszewska, and J. Rysz, "Pathomechanisms of immunological disturbances in β-thalassemia," International Journal of Molecular Sciences, vol. 22, no. 18, p. 9677, 2021.
  12. A. H. Mansourabadi, L. Mohamed Khosroshahi, F. Noorbakhsh, A. A. Hamidieh, and A. Amirzargar, "Isolation and in vitro Expansion of Regulatory T Cells from β-Thalassemia Major Kids and in vitro Evaluation of Their Plasticity and Inhibitory Effects in the Presence of Pro-Inflammatory Cytokines," International Archives of Allergy and Immunology, vol. 184, no. 1, pp. 63-75, 2023.
  13. Q. Ru, Y. Li, W. Xie, Y. Ding, L. Chen, G. Xu, et al., "Fighting age-related orthopedic diseases: focusing on ferroptosis," Bone Research, vol. 11, no. 1, p. 12, 2023.
  14. R. M. Matter, N. S. Elbarbary, E. A. R. Ismail, Y. W. Darwish, A. S. Nada, and V. P. Banoub, "Zinc supplementation improves glucose homeostasis in patients with β-thalassemia major complicated with diabetes mellitus: A randomized controlled trial," Nutrition, vol. 73, p. 110702, 2020.
  15. Y. Yi, M. Wu, H. Zeng, W. Hu, C. Zhao, M. Xiong, et al., "Tumor-derived exosomal non-coding RNAs: the emerging mechanisms and potential clinical applications in breast cancer," Frontiers in Oncology, vol. 11, p. 738945, 2021.
  16. S. M. MacKenzie, H. Saunders, J. C. van Kralingen, S. Robertson, A. Riddell, M-C. Zennaro, et al., "Circulating microRNAs as diagnostic markers in primary aldosteronism," Cancers, vol. 13, no. 21, p. 5312, 2021.
  17. A. Biswas, M. Maloverjan, K. Padari, A. Abroi, M. Rätsep, S. K. Wärmländer, et al., "Choosing an Optimal Solvent Is Crucial for Obtaining Cell-Penetrating Peptide Nanoparticles with Desired Properties and High Activity in Nucleic Acid Delivery," Pharmaceutics, vol. 15, no. 2, p. 396, 2023.
  18. D. Prisco, "Oral Communications and Posters 115th National Congress of the Italian Society of Internal Medicine," Allergology and Clinical Immunology, 2014.
  19. R. N. Kostoff, M. B. Briggs, D. Kanduc, S. Dewanjee, R. Kandimalla, Y. Shoenfeld, et al., "Modifiable contributing factors to COVID-19: A comprehensive review," Food and Chemical Toxicology, 2022.
  20. C. Sangokoya, M. J. Telen, and J-T. Chi, "microRNA miR-144 modulates oxidative stress tolerance and associates."

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