Vol 8 No 2 (2023): December
Medicine

Evaluation of Serum Fetuin-A as A Possible Marker for Polycystic Ovarian Syndrome Among Iraqi Women; Case-control Study


Ola Jamal Yasien
Department of Obstetrics and Gynecology, AL-Yarmouk Teaching Hospital, Baghdad, Iraq *
Fadia J. Al Izzi
College of Medicine/Al-Mustansiriya University, Al-Yarmouk Teaching Hospital, Baghdad, Iraq

(*) Corresponding Author
Picture in here are illustration from public domain image or provided by the author, as part of their works
Published August 31, 2023
Keywords
  • Fetuin-A,
  • Polycystic Ovarian Syndrome (PCOS),
  • Reproductive-aged Females,
  • Metabolic Syndrome,
  • Iraqi Women
How to Cite
Yasien, O. J., & Izzi, F. J. A. (2023). Evaluation of Serum Fetuin-A as A Possible Marker for Polycystic Ovarian Syndrome Among Iraqi Women; Case-control Study. Academia Open, 8(2). https://doi.org/10.21070/acopen.8.2023.7763

Abstract

Elevated levels of Fetuin-A, a protease inhibitor belonging to the cystatin family, have raised questions about its role in the pathogenesis of Polycystic Ovarian Syndrome (PCOS), the most prevalent endocrinopathy in reproductive-aged females. This case-control study, conducted in Iraq, aimed to assess changes in Fetuin-A levels among Iraqi women with PCOS. A convenient sample of 90 women, comprising 45 PCOS cases and 45 healthy controls, was enrolled. Fetuin-A levels were measured and found to be significantly higher in the PCOS group compared to controls. Additionally, significant positive correlations were observed between Fetuin-A levels and fasting plasma glucose, fasting serum insulin, insulin resistance, luteinizing hormone, and serum testosterone. Using a receiver operating characteristic curve, a cutoff point of 502.00 ng/mL was determined for predicting positive Fetuin-A levels, with a sensitivity and specificity of 84.4% and 73.3%, respectively. This study suggests that Fetuin-A could serve as a valuable marker for both screening and evaluating PCOS and its potential late consequences, including metabolic syndrome.


Highlights:

  • Elevated Fetuin-A Levels: This study reveals significantly higher Fetuin-A levels in PCOS, shedding light on its potential role in the pathogenesis of the syndrome.

  • Correlations with Metabolic Factors: Positive correlations between Fetuin-A and key metabolic markers like fasting glucose, insulin resistance, and luteinizing hormone highlight its relevance in the context of PCOS and metabolic health.

  • Screening Potential: The identified cutoff point for predicting positive Fetuin-A levels offers a promising tool for screening and evaluating PCOS and associated late consequences, particularly metabolic syndrome.

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