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Clinical Research

Vol 8 No 1 (2023): June

BMI and Male Infertility: Impact on Sperm Parameters and Hormones
Hubungan antara Indeks Massa Tubuh dan Parameter Sperma, Hormon Reproduksi, dan Implikasinya terhadap Infertilitas Pria



(*) Corresponding Author
DOI
https://doi.org/10.21070/acopen.8.2023.6374
Published
May 23, 2023

Abstract

This study aimed to assess the relationship between body mass index (BMI) and various indicators of men's reproductive health, specifically focusing on sperm parameters and levels of reproductive hormones, in individuals without recognized risk factors for infertility. The research employed a cross-sectional design, analyzing data from a sample of men. The results revealed a significant correlation between BMI and men's health indicators, demonstrating that BMI was associated with alterations in sperm parameters and reproductive hormone levels. Notably, BMI exhibited a negative connection with levels of both prolactin and testosterone. However, the findings emphasize the need for extensive, randomized, and prospective investigations to further elucidate the complex association between BMI and male infertility. These findings hold important implications for clinicians and researchers in the field, highlighting the importance of considering BMI as a potential risk factor for male infertility and advocating for additional research to inform diagnostic and therapeutic strategies targeting this population.

Highlights: 

  • The study establishes a significant correlation between body mass index (BMI) and indicators of men's reproductive health, specifically sperm parameters and reproductive hormone levels.
  • BMI demonstrates a negative association with prolactin and testosterone levels, highlighting the potential impact of BMI on male infertility.
  • The findings underscore the importance of considering BMI as a potential risk factor for male infertility and emphasize the need for further research to inform diagnostic and therapeutic strategies

Keywords : BMI, Male Infertility, Sperm Parameters, Reproductive Hormones, Risk Factors

 

References

  1. J. Boivin, L. Bunting, J. A. Collins, and K. G. Nygren, “International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care,” Hum. Reprod., vol. 22, no. 6, pp. 1506–1512, 2007, doi: 10.1093/humrep/dem046.
  2. G. R. Dohle, G. M. Colpi, T. B. Hargreave, G. K. Papp, A. Jungwirth, and W. Weidner, “EAU guidelines on male infertility,” Eur. Urol., vol. 48, no. 5, pp. 703–711, 2005, doi: 10.1016/j.eururo.2005.06.002.
  3. M. Ng et al., “Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.,” Lancet (London, England), vol. 384, no. 9945, pp. 766–781, Aug. 2014, doi: 10.1016/S0140-6736(14)60460-8.
  4. N. Sermondade et al., “BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis.,” Hum. Reprod. Update, vol. 19, no. 3, pp. 221–231, 2013, doi: 10.1093/humupd/dms050.
  5. P. Fedorcsák et al., “Impact of overweight and underweight on assisted reproduction treatment.,” Hum. Reprod., vol. 19, no. 11, pp. 2523–2528, Nov. 2004, doi: 10.1093/humrep/deh485.
  6. S. Helo et al., “A Randomized Prospective Double-Blind Comparison Trial of Clomiphene Citrate and Anastrozole in Raising Testosterone in Hypogonadal Infertile Men.,” J. Sex. Med., vol. 12, no. 8, pp. 1761–1769, Aug. 2015, doi: 10.1111/jsm.12944.
  7. X. Xu et al., “The Effect of Aromatase on the Reproductive Function of Obese Males.,” Horm. Metab. Res. = Horm. und Stoffwechselforsch. = Horm. Metab., vol. 49, no. 8, pp. 572–579, Aug. 2017, doi: 10.1055/s-0043-107835.
  8. S. on Obesity (1999: Geneva and W. H. Organization, “Obesity : preventing and managing the global epidemic : report of a WHO consultation.” World Health Organization, p. 252 p., 2000.
  9. W. H. Organization, “WHO laboratory manual for the examination and processing of human semen.” World Health Organization, p. Previous editions had different title : WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction, 2010.
  10. S. Alshahrani, A.-F. Ahmed, A. H. Gabr, M. Abalhassan, and G. Ahmad, “The impact of body mass index on semen parameters in infertile men.,” Andrologia, vol. 48, no. 10, pp. 1125–1129, Dec. 2016, doi: 10.1111/and.12549.
  11. L. M. Davidson, K. Millar, C. Jones, M. Fatum, and K. Coward, “Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility.,” Hum. Fertil. (Camb)., vol. 18, no. 3, pp. 184–193, Sep. 2015, doi: 10.3109/14647273.2015.1070438.
  12. R. Sharma, K. R. Biedenharn, J. M. Fedor, and A. Agarwal, “Lifestyle factors and reproductive health: taking control of your fertility.,” Reprod. Biol. Endocrinol., vol. 11, p. 66, Jul. 2013, doi: 10.1186/1477-7827-11-66.
  13. K. K. Shukla, S. Chambial, S. Dwivedi, S. Misra, and P. Sharma, “Recent scenario of obesity and male fertility.,” Andrology, vol. 2, no. 6, pp. 809–818, Nov. 2014, doi: 10.1111/andr.270.
  14. A. A. MacDonald, G. P. Herbison, M. Showell, and C. M. Farquhar, “The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis.,” Hum. Reprod. Update, vol. 16, no. 3, pp. 293–311, 2010, doi: 10.1093/humupd/dmp047.
  15. D. S. Colaci et al., “Men’s body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization.,” Fertil. Steril., vol. 98, no. 5, pp. 1193–9.e1, Nov. 2012, doi: 10.1016/j.fertnstert.2012.07.1102.
  16. L. Loukil, H. Hadj Kacem, A. Bahloul, and H. Ayadi, “Relation between male obesity and male infertility in a Tunisian population,” Andrologia, vol. 47, 2014, doi: 10.1111/and.12257.
  17. M. L. Eisenberg, S. Kim, Z. Chen, R. Sundaram, E. F. Schisterman, and G. M. Buck Louis, “The relationship between male BMI and waist circumference on semen quality: data from the LIFE study.,” Hum. Reprod., vol. 29, no. 2, pp. 193–200, Feb. 2014, doi: 10.1093/humrep/det428.
  18. A. O. Hammoud, N. Wilde, M. Gibson, A. Parks, D. T. Carrell, and A. W. Meikle, “Male obesity and alteration in sperm parameters.,” Fertil. Steril., vol. 90, no. 6, pp. 2222–2225, Dec. 2008, doi: 10.1016/j.fertnstert.2007.10.011.
  19. A. O. Hammoud, M. Gibson, C. M. Peterson, A. W. Meikle, and D. T. Carrell, “Impact of male obesity on infertility: a critical review of the current literature.,” Fertil. Steril., vol. 90, no. 4, pp. 897–904, Oct. 2008, doi: 10.1016/j.fertnstert.2008.08.026.
  20. E. R. M. Hofny et al., “Semen parameters and hormonal profile in obese fertile and infertile males,” Fertil. Steril., vol. 94, no. 2, pp. 581–584, 2010, doi: https://doi.org/10.1016/j.fertnstert.2009.03.085.
  21. J. E. Chavarro, T. L. Toth, D. L. Wright, J. D. Meeker, and R. Hauser, “Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic.,” Fertil. Steril., vol. 93, no. 7, pp. 2222–2231, May 2010, doi: 10.1016/j.fertnstert.2009.01.100.
  22. S. J. Parekattil and A. Agarwal, Male infertility: Contemporary clinical approaches, andrology, art & antioxidants. 2012. doi: 10.1007/978-1-4614-3335-4.
  23. M. Z. Keskin et al., “Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones.,” Arch. Ital. di Urol. Androl. organo Uff. [di] Soc. Ital. di Ecogr. Urol. e Nefrol., vol. 89, no. 3, pp. 219–221, Oct. 2017, doi: 10.4081/aiua.2017.3.219.
  24. K. Ehala-Aleksejev and M. Punab, “Relationships between total testicular volume, reproductive parameters and surrogate measures of adiposity in men presenting for couple’s infertility.,” Andrologia, Dec. 2017, doi: 10.1111/and.12952.
  25. A. O. Hammoud, M. Gibson, C. M. Peterson, B. D. Hamilton, and D. T. Carrell, “Obesity and male reproductive potential.,” J. Androl., vol. 27, no. 5, pp. 619–626, 2006, doi: 10.2164/jandrol.106.000125.
  26. A. Vermeulen, J. M. Kaufman, J. P. Deslypere, and G. Thomas, “Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men.,” J. Clin. Endocrinol. Metab., vol. 76, no. 5, pp. 1140–1146, May 1993, doi: 10.1210/jcem.76.5.8496304.
  27. J. B. Kerr, M. Millar, S. Maddocks, and R. M. Sharpe, “Stage-dependent changes in spermatogenesis and Sertoli cells in relation to the onset of spermatogenic failure following withdrawal of testosterone.,” Anat. Rec., vol. 235, no. 4, pp. 547–559, Apr. 1993, doi: 10.1002/ar.1092350407.

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