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Section Medicine

Pediatric NAFLD Epidemiology, Risk Factors and Research Gaps in Uzbekistan and India

Vol. 11 No. 1 (2026): June :
DOI : https://doi.org/10.21070/acopen.11.2026.13269
Published : Jan 5, 2026

Dinmukhammadieva Dilorom Rakhimjan kizi (1), Saurav Sunil Pawshe (2), Shadiyeva Soadat Ulmasovna (3)

(1) PhD of the department of Childrenʼs disease in family medicine, Tashkent State Medical University, Tashkent, Uzbekistan
(2) Final 6th course student, Tashkent State Medical University, Uzbekistan
(3) PhD of the department of Paediatric subjects Chemistry International University in Tashkent, Tashkent, Uzbekistan
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Abstract:

General Background: Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD) represents a critical chronic liver condition in children globally, characterized by hepatic fat accumulation without alcohol exposure, potentially progressing to steatohepatitis, fibrosis, and cirrhosis. Specific Background: Rapid socioeconomic transitions in Asia have escalated childhood obesity rates, with India reporting prevalence estimates of 12–63% among overweight children, while Uzbekistan demonstrates 50–66% prevalence in similar cohorts, though comprehensive epidemiological data remain limited. Knowledge Gap: No comparative analysis exists examining pediatric NAFLD patterns between Uzbekistan and India, particularly regarding temporal trends and population-based prevalence. Aims: This study compares burden, risk factors, and clinical characteristics of pediatric NAFLD across both nations through systematic literature review. Results: Both countries exhibit increasing prevalence driven by obesity and insulin resistance, with male preponderance and age-dependent patterns; however, Uzbekistan lacks population-based studies unlike India's more established epidemiological framework. Novelty: This represents the first cross-country comparison of pediatric NAFLD between Central and South Asian contexts. Implications: Findings underscore urgent need for standardized screening protocols, culturally adapted lifestyle interventions, and population-based research in Uzbekistan to inform national health policies.
Keywords : Pediatric NAFLD, Childhood Obesity, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome, Insulin Resistance
Highlight :



  • Prevalence reaches 42-47% among overweight Indian children, with boys consistently more affected.

  • Uzbekistan shows 50-100% rates in obese cohorts but lacks comprehensive population-based studies.

  • Both nations face growing burden from dietary transitions, urbanization, and sedentary lifestyles.

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