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Section Clinical Research

HbA1c Association With Transaminase Levels in Type 2 Diabetes

Hubungan HbA1c dengan Tingkat Transaminase pada Diabetes Tipe 2
Vol. 11 No. 1 (2026): June :
DOI : https://doi.org/10.21070/acopen.11.2026.12217
Published : Jan 4, 2026

Intan Dara Puspita (1), Syahrul Ardiansyah (2)

(1) Program Studi D4 Teknologi Laboratorium Medis, Universitas Muhammadiyah Sidoarjo, Indonesia
(2) Program Studi D4 Teknologi Laboratorium Medis, Universitas Muhammadiyah Sidoarjo, Indonesia
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Abstract:

General Background: Type 2 diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and progressive multisystem complications, including hepatic involvement. Specific Background: Hemoglobin A1c represents long-term glycemic control, while serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase are widely used biomarkers of hepatocellular injury in clinical practice. Knowledge Gap: Despite routine use of these parameters, evidence describing their statistical relationship in type 2 diabetes mellitus patients remains limited, particularly in Indonesian clinical settings. Aims: This study aimed to analyze the correlation between HbA1c levels and SGOT and SGPT levels in patients with type 2 diabetes mellitus. Results: A quantitative analytical cross-sectional design was applied to 30 patients aged over 45 years. Kendall’s tau-b analysis demonstrated a significant positive correlation between HbA1c and SGOT (p=0.000; r=0.557) and between HbA1c and SGPT (p=0.018; r=0.317), indicating moderate and low correlation strengths, respectively. Novelty: This study provides empirical evidence linking long-term glycemic control indicators with liver enzyme alterations among type 2 diabetes mellitus patients in a hospital-based Indonesian population. Implications: The findings suggest that elevated HbA1c levels are associated with increased liver enzyme levels, supporting the integration of glycemic monitoring and liver function assessment in the comprehensive management of type 2 diabetes mellitus.
Highlights:




  • Long-term glycemic status showed a statistically significant relationship with hepatic enzyme levels.




  • The association strength differed between transaminase parameters, with a stronger pattern observed for AST.




  • Elevated biochemical markers indicated potential hepatic involvement among older diabetic patients.




Keywords : Type 2 Diabetes Mellitus, HbA1c, SGOT, SGPT, Liver Function

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References

Kementerian Kesehatan Republik Indonesia, Survei Kesehatan Indonesia 2023, Jakarta, Indonesia: Kemenkes RI, 2023, p. 235.

D. Hartono, “Relationship Between Self-Care and Diabetes Mellitus Complications in Type II Diabetes Mellitus Patients at Internal Medicine Clinic of RSUD Dr. Mohamad Saleh Probolinggo,” Journal of Nursing Care and Biomolecular, vol. 4, no. 2, pp. 111–119, 2019.

N. Pratiwi, M. Nur, and T. Triwahyuni, “Relationship Between HbA1c Examination and Random Blood Glucose Levels With the Incidence of Type 2 Diabetes Mellitus at Pertamina Bintang Amin Husada Hospital Bandar Lampung,” Tusy Triwahyuni Innovation Journal of Social Science Research, vol. 3, no. 5, pp. 134–143, 2023.

A. Reza and B. Rachmawati, “Differences in SGOT and SGPT Levels Between Subjects With and Without Diabetes Mellitus,” Jurnal Kedokteran Diponegoro, vol. 6, no. 2, pp. 158–166, 2017.

E. Rampa, H. Sinaga, and N. Putri, “SGOT, SGPT, and Leukocyte Count Examination in Patients,” Journal of Medical Bioscience Analysis, vol. 8, no. 1, pp. 17–21, 2021.

I. Kurnia and E. Ismawatie, “Correlation Between HbA1c Levels and Creatinine Levels in Diabetes Mellitus Patients at Pramita Samanhudi Laboratory,” Journal of Medical Laboratory Research, vol. 1, no. 3, pp. 148–154, 2024.

A. S. Susilo, Z. Zulfian, and I. Artini, “Correlation Between HbA1c Values and Total Cholesterol Levels in Type 2 Diabetes Mellitus Patients,” Jurnal Ilmiah Kesehatan Sandi Husada, vol. 12, no. 2, pp. 640–645, 2020, doi: 10.35816/jiskh.v11i1.262.

A. Sanda, F. Mangarengi, and R. D. N. Pakasi, “Uric Acid Levels Correlated With Glycated Hemoglobin (HbA1c) Levels in Type 2 Diabetes Mellitus Patients,” Cermin Dunia Kedokteran, vol. 45, no. 6, pp. 405–407, 2018.

M. Pangestuningsih and F. Rukminingsih, “Description of Liver Function in Type II Diabetes Mellitus Patients at a Private Hospital in Demak Regency, October–December 2020,” Indonesian Journal of Pharmaceutical Research, vol. 4, no. 2, pp. 134–143, 2022.

D. O. Ginting et al., “Overview of Liver Function in Type 2 Diabetes Mellitus Patients at Royal Prima General Hospital Medan,” Jurnal Kesehatan Tambusai, vol. 5, no. 1, pp. 2025–2031, 2024.

S. Hartini, C. K. Khotimah, and N. Kusumawati, “Liver Function Profile in Diabetes Mellitus Patients Based on SGOT and SGPT Levels,” Gorontalo Journal of Health Sciences and Community, vol. 8, no. 1, pp. 25–33, 2024, doi: 10.35971/gojhes.v8i1.21931.

N. Dewi and S. Supriyadi, “Association of Hepatic Enzymes SGOT and SGPT in Type 2 Diabetes Mellitus Patients,” Jurnal Akademika Baiturrahim Jambi, vol. 13, no. 1, pp. 18–24, 2024, doi: 10.36565/jab.v13i1.619.

M. R. Maulana and S. Kuswarini, “Risk Analysis of SGOT and SGPT Enzyme Levels in Type 2 Diabetes Mellitus Patients,” Journal of Medical Laboratory, vol. 4, no. 1, pp. 51–55, 2022, doi: 10.31983/jlm.v4i1.8489.

Y. Xie, W. Kong, X. Wang, and Z. Wu, “Association of Glycated Hemoglobin With Non-Alcoholic Fatty Liver Disease and Severity of Liver Steatosis and Fibrosis Measured by Transient Elastography in Adults Without Diabetes,” BMC Endocrine Disorders, vol. 22, no. 1, pp. 1–10, 2022, doi: 10.1186/s12902-022-01134-z.

American Diabetes Association, “Introduction and Methodology: Standards of Care in Diabetes—2024,” Diabetes Care, vol. 47, suppl. 1, pp. S1–S4, 2024, doi: 10.2337/dc24-SINT.