Abstract

Background: Cancer remains a major global health challenge, characterized by the uncontrolled proliferation of abnormal cells. Specific Background: Emerging research suggests that ABO blood types may influence individual susceptibility to various cancers through immunological mechanisms. Knowledge Gap: However, limited studies have investigated the distribution and association of ABO blood groups with specific cancer types in the Iraqi population. Aim: This study aims to examine the relationship between ABO blood types and cancer risk among patients in Mosul, Iraq. Results: Data from 317 cancer patients revealed that blood group O was most prevalent among individuals with breast and colon cancer, while blood group A showed higher frequencies in lung and stomach cancers. Among leukemia cases, type O was predominant, especially in acute lymphocytic leukemia. Novelty: This study is one of the first in Iraq to explore the correlation between ABO blood groups and a spectrum of malignancies, providing region-specific insights into cancer epidemiology. Implications: Findings support the potential role of blood type as a biomarker for cancer susceptibility, offering a foundation for risk-based screening and personalized intervention strategies. Further genetic and longitudinal studies are warranted to clarify underlying mechanisms and enhance cancer prevention efforts.

Highlights:

1. Blood type O linked to breast and colon cancer cases.

2. Type A more common in lung and stomach cancer.

3. ABO typing aids early cancer risk identification.

Keywords: ABO blood group, cancer risk, leukemia, tumor classification, personalized medicine

Introduction

Cancer is a complex and multifactorial disease that affects millions of people worldwide. It is characterized by the uncontrolled proliferation of abnormal cells that can invade and damage surrounding tissues. This uncontrolled growth can lead to the formation of tumors, which may disrupt normal physiological functions. The World Health Organization (WHO) projects that cancer cases will rise to over 23 million by 2030, highlighting the urgent need for effective prevention and treatment strategies [1].

1.2-Definition and Classification of Tumors

Tumors are classified into two main categories: benign and malignant. Benign tumors do not spread to other parts of the body and are generally not life-threatening. In contrast, malignant tumors are cancerous and can invade nearby tissues, leading to metastasis, where cancer cells spread to distant organs. The classification of tumors is based on various criteria, including cell type, tissue of origin, and genetic mutations [2]. Understanding tumor biology is essential for developing targeted therapies and improving patient outcomes

1.3 The Role of Blood Types in Health

Blood groups are determined by the presence or absence of specific antigens on the surface of red blood cells. The ABO blood group system classifies blood into four types: A, B, AB, and O. Each blood type has distinct immunological characteristics that may influence health outcomes. For instance, the presence of particular antigens can affect an individual's susceptibility to infections and autoimmune diseases [3]. The role of blood types in cancer risk has gained attention, as certain blood group antigens may interact with the immune system, potentially influencing tumor development and progression.

1.4 Importance of Studying Blood Types and Cancer

Understanding the relationship between blood type and cancer risk is crucial for several reasons. First, it may provide insights into the mechanisms underlying cancer development, which can inform prevention strategies. Second, identifying blood types associated with higher cancer risk can enhance early detection efforts, allowing for timely intervention. Finally, this knowledge may lead to personalized treatment plans that consider a patient's blood type, improving therapeutic outcomes [4].

Methods

2.1 Data Collection

Data were collected from cancer patients treated in various hospitals in Mosul, Iraq, during the period from 2022 to 2024. Patient records provided information on age, sex, ABO blood type, and the pathological status of their cancer. Data collection was conducted in accordance with ethical guidelines, ensuring the confidentiality and anonymity of participants.

2.2 Materials Used

2.2 Materials Used

The following materials were utilized in the study:

1- Anti-ABO Serum: Used for blood typing.

2- Cotton Swabs: For sample collection.

3- Syringes: For blood extraction.

4- EDTA Tubes: For blood sample preservation.

5- Alcohol: For disinfecting the skin prior to blood collection.

A total of (317) cancer patient were included in the study, comprising (169) males and (148) females, providing a balanced representation of the population.

Result and Discussion

Result

3.1 Demographics of. Patients

The demographic data revealed a diverse patient population, with a wide range of ages and cancer types. This diversity enhances the validity of the findings, allowing for more generalized conclusions regarding the relationship between blood types and cancer risk [5].

3.2 Differential Diagnosis Of Patients

The Frequency Of Various Cancer Types Among The 317 Essential Iraqi Patients Is Summarized In Table 1. This Information Is For Understanding The Distribution Of Different Malignancies Within The population [6].

3.3 ABO Blood Group Frequencies

The frequency of ABO blood group phenotypes among patients with different types of leukemia is detailed in Table 2. Understanding these frequencies is crucial for identifying potential associations between blood type and specific cancer types [7].

3.3 Characteristics According to Blood Type

The characteristics of patients based on their blood type are summarized in Table 3. This information provides insights into the demographic and clinical profiles associated with each blood type. Table: 3.

The data indicate that blood group O has the highest frequency in breast cancer, followed by A and B. Additionally, blood group O also shows high prevalence in colon cancer, while blood group A is more common in lung and stomach cancers. These findings suggest that blood type may influence cancer susceptibility.

4. Literature Review

4.1 Previous Research on Blood Types and Cancer

Numerous studies have explored the connection between blood type and cancer risk. Research has indicated that blood group antigens may play a role in determining an individual's immune response, which could affect their susceptibility to different cancers. For instance, some studies have reported an association between type a blood and an increased risk of gastric cancer, while others have found type O blood may be linked to a reduced risk of certain cancers. However, results are sometimes conflicting, highlighting the need for further research to elucidate these dynamics [8, 9, 10].

4.2 Current Understanding of Blood Group Antigens

The biological role of blood group antigens remains a topic of ongoing research. Some studies suggest that these antigens may interact with various immune system components, potentially influencing cancer development and progression. For example, the presence of certain antigens might affect the ability of the immune system to recognize and eliminate cancer cells [11, 12]. Understanding these interactions could provide valuable insights into cancer prevention strategies and therapeutic interventions.

Discussion

5.1 Implications of Findings

The findings of this study suggest a potential association between blood type and certain cancers, with variations observed across different blood types. Notably, individuals with type a blood may face a heightened risk of gastric cancer, while type O blood might be linked to a reduced risk for specific malignancies. These insights could inform early detection and treatment strategies, allowing healthcare providers to tailor screening and therapeutic approaches based on individual risk profiles [6, 13].

5.2 Further Research Directions

Future investigations should focus on exploring the effects of blood types on other cancers that have not been adequately studied. Advanced techniques, such as genetic analysis, could help elucidate how genetic and environmental factors shape the relationship between blood type and cancer. Additionally, longitudinal studies are recommended to track cancer development over time, thereby enhancing our understanding of whether blood types influence long-term cancer outcomes [14].

6. Ethical Considerations

Ethical considerations were carefully addressed during this study. Necessary approvals were obtained from the relevant ethics committee, ensuring the protection of participants' privacy and confidentiality. Measures were implemented to secure data collection and analysis, minimizing any potential risks associated with personal information. The overarching goal of this research is to contribute to scientific knowledge while safeguarding the rights and welfare of participants [15].

Conclusion

In conclusion, this study reinforces the potential link between ABO blood types and cancer susceptibility. The findings provide a foundation for further research aimed at understanding this complex relationship, which could ultimately lead to improved cancer prevention and treatment strategies. By recognizing the significance of blood type in cancer risk, healthcare professionals can develop tailored interventions that enhance patient outcomes [3, 16].

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