Academia Open
Vol 10 No 1 (2025): June (In Progress)
Medicine

Physiology of Nerve Supply for Renal System
Fisiologi Suplai Saraf untuk Sistem Ginjal


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  • Wathiq Faraon Hussein*
Wathiq Faraon Hussein
Department of Basic Science, College of Nursing, University of Basrah, Basrah, Iraq *

(*) Corresponding Author
Picture in here are illustration from public domain image or provided by the author, as part of their works
DOI: https://doi.org/10.21070/acopen.10.2025.10605
Published February 11, 2025
Keywords
  • Renal Nerves,
  • Sympathetic Regulation,
  • Hypertension,
  • Neurotransmitters,
  • Renal Denervation
How to Cite
Hussein, W. F. (2025). Physiology of Nerve Supply for Renal System. Academia Open, 10(1), 10.21070/acopen.10.2025.10605. https://doi.org/10.21070/acopen.10.2025.10605

Copyright (c) 2025 Wathiq Faraon Hussein

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

General Background: The renal nervous system regulates kidney function through sympathetic and sensory neurons, impacting blood pressure and fluid balance. Specific Background: Renal nerve hyperactivity is linked to hypertension and metabolic disorders, prompting interest in renal denervation as a treatment. Knowledge Gap: The precise mechanisms by which renal nerves influence disease remain unclear, and clinical outcomes of renal denervation are inconsistent. Aims: This review explores renal nerve structure, neurotransmission, and functional roles in health and disease. Results: Sympathetic nerves release norepinephrine and co-transmitters, affecting vascular resistance and sodium handling, while sensory nerves modulate sympathetic output. Novelty: It integrates recent findings on renal neurophysiology, emphasizing afferent-sympathetic interactions. Implications: Advancing knowledge of renal nerves could refine treatments for hypertension and kidney disorders.

Highlights:

  • Renal nerve signaling controls blood pressure and kidney function through neurotransmitters like norepinephrine and ATP.
  • Renal denervation therapy shows potential for treating hypertension but has inconsistent clinical outcomes.
  • Afferent-sympathetic interaction plays a crucial role in kidney function and systemic homeostasis

Keywords: Renal Nerves, Sympathetic Regulation, Hypertension, Neurotransmitters, Renal Denervation

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